Nuvia™ cPrime™ Hydrophobic Cation Exchange Media

Nuvia cPrime hydrophobic cation exchange media are a new addition to Bio-Rad's family of mixed-mode purification products. These media are designed for process-scale purification of a wide variety of therapeutic proteins.

Nuvia cPrime media's unique selectivity allows method developers to use hydrophobic and cation exchange interaction modes to achieve effective purification. More importantly, the media have a large design space for binding and elution, allowing for the development of highly robust methods in a commercial manufacturing setting. Nuvia cPrime media are built on a rigid, mechanically and chemically stable macroporous base matrix with a particle size optimized to deliver exceptional flow properties, fast mass transfer, and stability.

The balance between hydrophobicity, charged interaction, and the highly hydrophilic base matrix of Nuvia cPrime empowers method developers with new ways to directly exploit various modes of interaction to purify challenging or sensitive protein or to separate closely related protein species, such as isoforms and variants from post-translational modifications, product aggregation, and degradation.

Nuvia cPrime delivers value by providing:

• New and unique selectivity
• Salt tolerant media
• Simple method development
• Large design space for capture and elution of a variety of biotherapeutic proteins
• High recovery of target protein
• Mechanical and chemical stability