Application Note

NatriFlo HD-Q Membrane Adsorber Comparison Study

Source: Natrix Separations

Strong anion exchange (Q) chromatography has become an industry standard in the polish purification steps of mAb production. It is a proven technology to remove DNA, viruses, endotoxins and acidic host cell proteins from process feed streams in flowthrough mode.

As the industry pursues an increasing interest in downstream single-use technolo­gies and flexible biomanufacturing due to advancements in cell culture technology and the emergence of cost-sensitive biosimilars, conventional purification technol­ogies present limitations.

Despite their high binding capacity, traditional resin-based chromatography col­umns are often oversized due to throughput limitation and are not suitable for flex­ible biomanufacturing. Conventional membrane adsorbers, meanwhile, offer faster throughput, but cannot provide sufficient process robustness due to the low bind­ing capacity typical of most membranes. These factors impose challenges on the design of purification schemes for manufacturing of biotherapeutics.

NatriFlo HD-Q membrane adsorbers overcome these limitations by combining high binding capacity and high flow rates to deliver best-in-class performance in single-use plug & flow format.

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