Method Expert: Guided, Automated Method Development For The LA-950

By HORIBA Instruments, Inc.

Developing an appropriate method for measuring particle size distribution in liquids using laser diffraction requires a structured approach. Samples analyzed as liquid dispersions include suspensions, emulsions, and solids dispersed in liquid. These three general categories of samples have a few unique considerations, but the majority of the content in this document will be applicable to all.

Suspensions and emulsions can sometimes be easily measured using the continuous phase of the original sample as the diluent in the analyzer. Proper dispersion of powders into a liquid may require the additional efforts of wetting and stabilization.

In all cases the basic goals remain the same; decide what the purpose of the measurement is, place a representative sample into the analyzer, disperse the sample in a liquid that does not dissolve or alter the particles, choose appropriate system settings for the measurement, and test for repeatability and reproducibility.