Mechanisms Of LNP-Mediated mRNA Delivery

By Michael Nguyen, PhD

Lipid nanoparticles (LNPs) have emerged as the premier option for mRNA delivery. Some aspects that make LNPs and mRNA a desirable pairing include how lipid layers form a protective shield around the mRNA that prevents enzymatic degradation by ribonucleases and the way LNPs form stable complexes with mRNA.

With mRNA-LNP vaccines paving the way, there have been recent FDA clearances for LNP-based gene editing clinical trials for rare diseases and cancer treatment. Explore the details supporting LNP-mediated mRNA delivery, as well as the challenges facing mRNA based therapeutics in the future.