Hygienic processing places high demands on the reliability and cleanability of production facilities. These requirements are especially high in separation processes like filtration and chromatography and are significant in ensuring purity of media by maintaining sterile process conditions. The mixing of different media in the manufacture of nutrient solutions as well as processes like fermentation demand absolute sterility. Common challenges such as corrosion in pipe systems, valve manifolds and tank installations in different pharmaceutical and biotech facilities can be reduced by using multiport valves and complex multiport-based manifolds. Multiport solutions such as the Robolux valve solution from Bürkert Fluid Control Systems were developed with such highpurity installations in mind.