Hetrotrimeric Gq Proteins Specific Inhibitor: YM-254890

YM-254890 is a cyclic depsipeptide isolated from a soil bacterium Chromobacterium sp. QS3666 strain and has a cyclic peptide structure composed of unique amino acids differing from normal amino acids. It specifically inhibits signals mediated by G q, G11 and G14, which are G q family of heterotrimeric G proteins and are involved in elevated Ca2+ level among about 20 types of G proteins, by acting on GDP/GTP exchange reaction. It is a first membrane permeable compound particularly inhibiting G q signal and a useful tool for a study analyzing G q signals.