Gene Profile Assays
Gene Profile Assays in Human Liver Cells
Using the human liver cell line HepG2, and a battery of 13 reporter constructs, this assay generates Gene Profiles for fundamental pathways of biological activity and toxicity. Cellular events such as DNA damage, protein perturbation, cell cycle perturbation, oxidative stress, metal ion contamination, aromatic hydrocarbon metabolism, signal transduction and retinoid activity can all be assessed. Additional constructs are available, and the assay continues to be upgraded as new constructs relevant to safety and efficacy come on line.
Gene Profile Assays in Human Colon Cells
This assay uses a human colon cell line as host to 7 reporter constructs focused on the assessment of DNA damage, and DNA damaging agents. Additional constructs are available, and the assay continues to be upgraded as new constructs relevant to safety and efficacy come on line.
Gene Profile Assays in Bacterial Cells
By using the bacterium E.coli to host a battery of 13 reporter constructs, this Gene Profile Assay enables the user to assess fundamental processes of toxicity that are relevant to both bacteria and mammalian cells. The construct battery covers the assessment of biological activities and toxicity associated with: DNA damage, oxidative stress, protein perturbation, and metal contamination.
Xenometrix, Inc., 2425 North 55th Street, Boulder, CO 80301-5700. Tel: 303-447-1773; Fax: 303-447-1758.