Balancing The Need For Complete Characterization Of Protein-Protein Interactions

Protein formulation is becoming increasingly complex due to the complexity of the biomolecules to be formulated and regulatory necessities in the process.  Drug product development researchers need reliable data on how the formulation of their biologics can impact potential aggregation, physical/chemical instability, and viscosity issues before proceeding too far down the development road. This paper looks at both Kd and B22 as predictors of formulation success, and potential drawbacks of each."