Automated Sampling Using The Bioprocess Autosampler For The Analysis Of An E. coli Fermentation Process

During process development, it is appropriate to compare many process conditions and analyze them at multiple time points during the bioprocess run. This strategy requires a substantial number of samples.

Explore how an autosampler and bioreactor pairing was used for the sampling of eight parallel fermentation runs and for storing the samples in a cooling stack. In the first use case, the samples were used to evaluate protein stability under different storage conditions. In the second use case, the samples were used to analyze the quality of plasmid DNA (pDNA) stored at different temperatures.