Antibody Collection Product Update
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For more information: www.origene.com/antibody
The OriGene Antibody Collection Product Update has been obtained from suppliers that adhere to the highest quality standards. Currently OriGene is supplied by Cell Signaling and LifeSpan to provide coverage for our Kinase and GPCR cDNA clone collections. Below are excerpts and links from both supplier's web sites.
The genomic era has yielded a wealth of new genes for which function and inter-relationships remain unknown. At the same time there is an increasing appreciation of the limits of what can be learned from gene expression profiling, and of the need to examine protein expression and activity. Activation-state-specific antibodies have proven to be a convenient and reliable set of tools in the new post-genomic "research toolbox". Cell Signaling Technology, Inc. (CST) is committed to developing innovative new research tools such as these to help define the mechanisms underlying cell function and disease, and thereby broadly accelerate progress in biomedical research and medicine.
CST strives to make novel antibodies of the highest possible quality by producing them in-house and rigorously characterizing them with respect to specificity and sensitivity. Production begins with extensive purification (typically by both protein A and peptide affinity chromatography) followed by testing by our staff scientists on a wide range of applications, including ELISA, western blotting, immunoprecipitation, immunocytochemistry, immunohistochemistry and flow cytometry.
LSB offers the industry's largest inventory of rabbit polyclonal anti-human peptide antibodies to gene families including the G Protein-Coupled Receptors (GPCRs), Nuclear Receptors (NRs), and Kinases. LifeSpan's antibodies have been optimized for use in human tissue immunohistochemistry. The expression pattern of each antibody has been screened across a panel of at least 50 tissues and compared to other proprietary or commercially available antibodies. Antibodies are selected for those that show the strongest concordance to existing literature and known patterns of expression in other species, and for their affinity and specificity to their targets. Many of these antibodies are multi-functional and can be used in other assays such as cell sorting or Western blots.
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