Application Note

A High-Throughput Static Culture Flask Alternative To Shake Flask Culture


By Brandy Nunez, Brian Canna, MBA, and Jessie Ni, PhD

Irvine Scientific specializes in developing and manufacturing cell culture media for bioproduction. To ensure the utility of the medium, CHO cell lines are tested for density, viability and productivity. The cell lines are tested at the small scale in conventional shake flasks. Gram level production of proteins and antibodies can be laborious using this type of in vitro method. Irvine Scientific is investigating a new membrane flask technology to increase small scale production levels and to decrease culture maintenance requirements.