FROM THE EDITOR

  • Bayer Change Notification Process For Raw Material Supply Encourages Supplier Collaboration And Transparency
    Bayer Change Notification Process For Raw Material Supply Encourages Supplier Collaboration And Transparency

    When it comes to raw material supply, increased regulatory focus on the raw material supply chain is creating a transformational change in the industry. Because of this, quality agreements create a responsibility among suppliers to notify their partners with advanced notice any time a change is made to the raw materials those partners are receiving. To ensure change notifications are handled properly and evaluated thoroughly, Bayer Healthcare utilizes an internal process that allows notifications to be filtered to the appropriate stakeholder and reviewed thoroughly before action is taken. Albert Obrero, Jr., Senior Project Specialist at Bayer HealthCare, recently presented the Bayer process to an audience at Bioprocess International 2014, where he outlined how it works as well as its benefits.

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BIOPROCESS INSIGHT

  • Time Savings With Simplified Cell Culturing
    Time Savings With Simplified Cell Culturing

    This application note describes how ReadyToProcess WAVE 25 can help reduce hands-on time as much as 25% in fed-batch culturing, while delivering excellent culture performance. For an optimized perfusion application, the use of intelligent control software enabled accurate regulation of process parameters. Over 100 × 106 viable cells/mL was easily achieved in seven days.

  • Cultivation Of Aggressive Microbial Cultures Of Pichia And Bacillus
    Cultivation Of Aggressive Microbial Cultures Of Pichia And Bacillus

    Advances in single-use bioprocess technology have led to the rapid adoption of single-use bioreactors (S.U.B.s) across a broad range of applications within the biotechnology industry.

  • Scale-Up Of Microbial Fermentation Using Recombinant E. Coli
    Scale-Up Of Microbial Fermentation Using Recombinant E. Coli

    Fermentation production facilities can utilize the Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) instead of traditional stainless steel cleaning-in-place/ sterilization-in-place (CIP/SIP) fermentor vessels without modifying their existing procedures.

  • Gas Analysis Mass Spectrometry In Fermentation And Cell Culture Processes

    As a PAT tool, on-line analysis of the inlet and outlet gases of sparged fermentors, provide an ideal means of characterizing the fermentation state. Key indicators include the Carbon Dioxide Evolution Rate, Oxygen Uptake Rate and the ratio of these two parameters: the Respiratory Quotient (RQ). These measurements are used to monitor and control the process and can help determine when to transfer a seed tank culture to inoculate the fermentor or detect contamination by foreign microorganism. Furthermore, these indicators allow for checking the cell density, comparing with historical trend data to verify the process is proceeding normally, and verifying batch completion.

  • The Benefits Of High Performing Chromatography Resins

    POROS® resins offer unique performance attributes and drive benefits to downstream processing. POROS® XQ resin is the newest addition to our product portfolio. This high-capacity, salt-tolerant, high-resolution anion exchanger enables unique selectivity, better separation, higher product yields, and reduced cost of goods. This application data will demonstrate the benefits of POROS® XQ resin to capture and polish chromatography in downstream purification.

  • Introducing One-Step Selectivity In The Purification Of Biological Products

    CaptureSelect™ purification and affinity separation products are developed for the discovery and manufacturing of therapeutic proteins, including antibodies and antibody fragments. These products enable a reduced time-to-market, increased purity and yield, and an overall lower cost of goods for biopharmaceutical development.

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FEATURED PRODUCTS

  • Synthetech Pharmaceutical Intermediates and Custom Synthesis
    Synthetech Pharmaceutical Intermediates and Custom Synthesis The Synthetech product offering includes specialty amino acids, peptide building blocks and fragments, and proprietary custom chiral intermediates for the pharmaceutical, biotech, and cosmeceutical industries.
  • Online Training: Design And Construction/Installation (Facilities And Equipment) Get the latest information on requirements for product and personnel protection, containment, and environmental safety. Understand the implication of personnel and materials flow on layout, as well as the materials and methods of construction of equipment and facilities, particularly from the perspective of cleanliness, functionality, and maintainability.
  • Tech Transfer / Scale-Up Management
    Tech Transfer / Scale-Up Management

    The Challenge A new customer was having critical quality compliance issues with another CMO. They contracted Patheon to manufacture their sterile lyophilized drug product which was marketed globally, but had only previously been manufactured in the United States.

  • Steam-Thru II Connections: Transition From Stainless And Single-Use Systems
    Steam-Thru II Connections: Transition From Stainless And Single-Use Systems

    Steam-Thru® II Connections provides a quick and easy sterile connection between biopharmaceutical processing equipment and single-use assemblies.

  • Handheld Particle Counter - MET ONE HHPC 6+
    Handheld Particle Counter - MET ONE HHPC 6+

    The MET ONE HHPC 6+ is a full featured six channel handheld particle counter designed for a wide range of tasks in high technology cleanroom manufacturing environments such as semiconductor or flat panel display manufacturing.

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BIOPROCESS ONLINE VIDEOS

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FEATURED SUPPLIERS

  • Thermo Scientific
    Thermo Scientific

    The Thermo Scientific HyClone product line in Logan, Utah helps to make the world healthier, cleaner and safer by producing leading cell culture products and bioprocessing systems for life-science research and protein-based drug production

  • Patheon Inc.
    Patheon Inc.

    Patheon Inc. is a leading provider of contract development and manufacturing services to the global pharmaceutical industry. Patheon provides products and services to more than three hundred of the world’s leading pharmaceutical and biotechnical companies.

  • Eppendorf, Inc
    Eppendorf, Inc

    Eppendorf has long been considered a vanguard in the rapidly evolving Life Science industry. Today, our company continues to play a critical supporting role in the development of emerging therapies and technologies. We are proud to support an industry that improves people’s lives, enhances quality of life, and profoundly shapes the human condition.

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ABOUT BIOPROCESS ONLINE

Welcome to BioProcess Online, the premier Internet source of useful and timely information for the worldwide BioProcess and life sciences industries. This site is designed to serve the needs of laboratory directors, laboratory managers, researchers, scientists, university faculty members, business executives, and other industry professionals. BioProcess Online provides daily news updates and in-depth feature stories about drug discovery, research and development advancements, university-industry collaborations, and regulatory issues.

On this site, industry professionals will find information about new products and technology, bioanalytics, bioreactors, biopurification, bioproduction products, bioprocess sensors, cell culture media, biopharm contract manufacturing, chromatography, lab informatics, lab automation, laboratory systems and equipment, molecular and cell biology, pipettors, assay instruments, genetic sequencing, immunochemicals, enzymes, hardware and software systems, and more.

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January 6, 2015
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Identifying and Closing the Training Gap in Clinical Research

January 6, 2015
1pm-2:30pm EST, Online Training

Building Accountability on Your Clinical Teams

January 8, 2015
1pm-2:30pm EST, Online Training

Pediatric Clinical Trials: Special Considerations and Requirements

January 12, 2015
1pm-2:30pm EST, Online Training

Root Cause Analysis for GCP – A Risk Action Plan Guide

January 16, 2015
1pm-3pm EST, Online Training
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